Calcium Pump Overexpression and Myocardial Function
نویسندگان
چکیده
منابع مشابه
Calcium pump overexpression and myocardial function. Implications for gene therapy of myocardial failure.
The contraction-relaxation cycle of the heart is controlled by the sequential rise and fall of the cytosolic calcium concentration. Calcium entry through L-type calcium channels during the action potential serves to trigger calcium release from the sarcoplasmic reticulum (SR) leading to activation of contractile proteins and force generation (for review, see Reference 1). In addition, there is ...
متن کاملStructure and function of the calcium pump.
Active transport of cations is achieved by a large family of ATP-dependent ion pumps, known as P-type ATPases. Various members of this family have been targets of structural and functional investigations for over four decades. Recently, atomic structures have been determined for Ca2+-ATPase by X-ray crystallography, which not only reveal the architecture of these molecules but also offer the op...
متن کاملThe plasma membrane calcium pump: structure, function and regulation.
17. Ovchinnikov, Yu. A. (1987) Trends Biochem. Sci. 12,434-438 18. Hara, Y., Urayama, 0.. Kawakami, K.. Nojima, H., Nagamune, H., Kojima, T., Ohta, T., Nagano, K. & Nakao, M. (1988) J. Biochem. (Tokyo) 102,43-58 19. Takeyasu, K., Tamkun, M. M., Renaud, K. J. & Fambrough, D. M. ( 1 988) J. Biol. Chem. 263,4347-4354 20. Maunsbach, A. B., Skriver, E., Soderholm, M. & Hebert, H. ( 1988) in Progress...
متن کاملCalcium Pump
Active transport of cations is achieved by a large family of ATPdependent ion pumps, known as P-type ATPases. Various members of this family have been targets of structural and functional investigations for over four decades. Recently, atomic structures have been determined for Ca2+-ATPase by X-ray crystallography, which not only reveal the architecture of these molecules but also offer the opp...
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Prohibitin (PHB) is a highly conserved protein implicated in various cellular functions including proliferation, apoptosis, tumor suppression, transcription, and mitochondrial protein folding. However, its function in diabetic cardiomyopathy (DCM) is still unclear. In vivo, type 2 diabetic rat model was induced by using a high-fat diet and low-dose streptozotocin. Overexpression of the PHB prot...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1998
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.83.9.966